National Center for Theoretical Sciences (North)
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Critical Phenomena and Complex Systems Focus Group
Coordinator : 陳俊仲教授 (Prof. Chun-Chung, Chen)
Committee members : Shu-Chiuan Chang (NCKU), Chi-Ming Chen (NTNU), Chi-Ning Chen (NDHU), Shu-Heng Chen (Natl. Chengchi U.), Chung-I Chou (Chinese Culture U.), Ming-Chung Ho (Natl. Kaoshiung Normal U.), Chin-Kun Hu (AS), Ming-Chang Huang (Chung-Yuan Christian U.), I-Ming Jiang (Natl. Sun-Yat Sen U.), hai-Yu Lin (Natl. Chung Cheng U.), Ning-Ning Pan (NTU), Wen-Jer Tzeng (Tamkang U.), Ming-Chya Wu (NCU)
Brief Description (請點選以下項目)
Members | Highlights | Visitors | Activities | Publications | Collaborations
Highlights of Research Results
1. RNA folding is a very difficulty theoretical problem. Most earlier studies neglect pseudo knots in the theoretical calculations. E. Sh. Mamasakhlisov (a visitor of this FG), Shura Hayryan, and Chin-Kun Hu included pseudo knots in the calculation and studied RNA folding in the presence of counterions. They found that the freezing and melting temperature of RNA decrease linearly with the logarithm of the ion strength [Phys. Rev. E75, 061907 (2007)], which is consistent with experimental observation.
2. Under partial support by NCTS (North), Prof. David B. Saakian (Yerevan Physics Institute) had visited NCTS (North) and Institute of Physics of Academia Sinica several times since 2004. He and Dr. Chin- Kun Hu published several papers at Proc. Natl. Acad. Sci. USA, Phys. Rev. E, and J. Stat. Phys.. In these papers, very general fitness functions for biological evolution models have been studied. Hu was invited to give a talk at 19th International Conference on Noise and Fluctuations on 9-14 September 2007 in Tokyo on "Quantum and lattice models of biological evolution". The brief text of the talk was published at AIP Conference Proceedings 922 (AIP, New York, 2007) edited by M. Tacano, Y. Yamamoto, and M. Nakao, pp. 589-594.
3. Prof. Chi-Tin Shih (Physics Department, Tanghai University), Stephan Roche (CEA, France), and Rudolf A. Romer (University of Warwick, UK) studied point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective single-strand or double-strand tight-binding models which simulate hole propagation along the DNA, a statistical analysis of charge transmission modulations associated with all possible point mutations is performed. They that in contrast to non-cancerous mutations, mutation hotspots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis. Their paper was submitted to Phys. Rev. Lett. for publication.
4. M.-C. Wu, Z. R. Struzik, E. Watanabe, Y. Yamamoto, and C.-K. Hu studied the temporal evolution for the phase histogram of ECG during human ventricular fibrillation. They found that some type of phase distribution is fatal. Their result was first published at AIP Conference Proceedings 922, (AIP, New York, 2007) edited by M. Tacano, Y. Yamamoto, and M. Nakao, pp. 573-576. A paper to be submitted to a journal is under preparation.